Serious severity

Blastomycosis (Systemic Fungal Infection)

A serious infection caught by inhaling fungal spores from damp soil, which can spread from the lungs to the eyes, skin and other organs. Rare in cats but potentially life-threatening.

⚠️ Common symptoms

Laboured breathing, coughing or rapid breathingPersistent fever that does not respond to ordinary antibioticsLoss of appetite and weight lossLethargy and general malaiseNon-healing skin lumps or draining soresCloudy, red or painful eyes and sudden vision lossLameness in some cases

Blastomycosis is a systemic fungal infection that, while uncommon in cats, can be extremely serious. It begins when a cat inhales the spores of Blastomyces, a fungus that grows in moist, acidic soil and decaying wood in particular parts of the world, often around rivers and lakes. The spores are too small to see, and simply disturbing contaminated soil can release them into the air to be breathed in.

Once in the lungs the fungus establishes an infection that frequently causes coughing, rapid or laboured breathing and a stubborn fever, and from there it can spread through the bloodstream to distant sites. The eyes are a common target, where infection causes inflammation, cloudiness and sometimes sudden blindness; the skin may develop lumps and draining sores; and the bones, brain and other organs can be affected too. Because the early signs — fever, poor appetite, weight loss and breathing trouble — resemble so many other illnesses and do not improve with routine antibiotics, the diagnosis is easily missed unless the fungus is specifically looked for.

Vets confirm it by finding the organism in samples from affected tissue or fluid, supported by chest imaging and specialised urine or blood tests. Treatment is a long haul: months of antifungal medication, careful monitoring of the liver, and supportive care for cats struggling to breathe. The outlook depends heavily on how early treatment starts and how much of the body is involved — cats caught early can recover well, while those with widespread disease or severe lung involvement have a more guarded prognosis. Reassuringly, the infection is acquired from the environment rather than passed between animals or from cats to their owners through everyday contact.

🔍 Causes

The infection is caused by the fungus Blastomyces, which lives in moist, acidic soil and rotting wood, especially near rivers and lakes in certain geographic regions. Cats become infected by inhaling microscopic spores from disturbed soil; the spores settle in the lungs and can then spread through the bloodstream to the eyes, skin, bones and nervous system. It is not spread from cat to cat or from cats to people through normal contact.

🛡 Prevention

There is no vaccine and the fungus cannot be eliminated from the environment, so prevention is limited. In regions where the disease occurs, reducing a cat's exposure to damp, spore-rich soil near waterways and wooded areas lowers the (already low) risk. The most useful protection is awareness: in endemic areas, unexplained breathing trouble, fever or eye and skin changes should prompt early testing so treatment can begin quickly.

💊 Treatment

Blastomycosis is treated with a prolonged course of antifungal medication — typically itraconazole or, in severe cases, amphotericin B — given for many months and continued for a period after signs resolve to prevent relapse. Cats with significant lung involvement may need oxygen support and hospitalisation early on, and affected eyes sometimes require additional treatment or, if severely damaged, removal. Because the drugs affect the liver, periodic blood tests monitor for side effects, and treatment is guided by a vet throughout.

When to see a vet: Seek veterinary care promptly for any cat with laboured breathing, a lingering fever that antibiotics do not touch, sudden eye problems or vision loss, or non-healing skin sores — especially in or after travel to a region where the fungus is found. Blastomycosis can be rapidly progressive, so early diagnosis and antifungal treatment markedly improve the chances of recovery.

⚕️ Medical disclaimer

  • This information is educational only and is not a substitute for veterinary advice.
  • Symptoms overlap between conditions — only a vet can diagnose accurately.
  • Never withhold treatment or self-medicate based on information found online.
  • When in doubt, call your vet. Early intervention almost always leads to better outcomes.